Product Name：D-Neopterin
Molecular Formula: C9H11N5O4
CAS Number:2009-64-5
Formula Weight:253.2
Description: White or Yellow powder
Biochemical functions: Neopterin has two isomers (D- and L- Neopterin). We sell only D- Neopterin. D-Neopterin is the natural form. The determination of neopterin concentrations is a sensitive method of monitoring the activity of the cellular immune system because of the close association of the stimulation of T-lymphocytes, the release of interferon and the synthesis of neopterin.
The levels of neopterin are higher in patients with certain infections ,with some tumours, with autoimmune diseases and in those rejecting transplants.
Dihydroneopterin triphosphate is part of the synthesis pathway of tetrahydrobioptrinm, an important cofactor in humans.
Solubility: Neopterin is practically insoluble in water. its solubility is about 0.005 g per 100 g of water (220C). Concentrated solutions may be prepared using 0.05M NaOH. Ultrasonication may be used to improve dissolution.
Analytical methods:
HPLC conditions: Column: Waters Spherisorb S5 ODS1
Eluant: 10mM Na2HPO4 PH 6
Flow rate: 1ml/min
Wavelength: 254nm
Sample: 1mg/ml 0.05N NaOH
TLC conditions: Stationary phase: cellulose
Eluant: water
Specifications: Purity: HPLC >99.0%
TLC one blue fluorescent spot at 366nm
Stability: Neopterin is light sensitive. Neopterin contains half a mole of water.
Storage: Keep the powder dry in tightly closed bottle coloured , at –200C. Neopterin can be transported without the use of dry ice. In tightly closed bottle, wrapped in aluminium foil, it is stable at ambient temperature for several months.
Uses: Neopterin is an important standard for analytical work .it can be used in the screening of blood donors for various diseases.
Safety information: Neopterin is known to be safe and there are no special precautions required in handling this product.
